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Read this before you try semaglutide for weight loss – A detailed guide
Obesity is a serious chronic disease that affects more than 70 million adults in the USA. Excessive body fat and uncontrolled weight gain are responsible for cardiovascular diseases, diabetes, gallbladder disease, and arthritis. A lot of research and effort has been conducted to find a safe and sustainable weight loss management treatment, and one such miracle drug has been discovered that can promote effective weight loss with minimal side effects.
On June 4th, 2021, FDA approved the use of Semaglutide for the management of chronic obesity. Initially, Semaglutide was used to treat type 2 diabetes, but research indicates, and the medical community agrees that Semaglutide can also be used as an anti-obesity weight loss medicine.
What is Semaglutide, and how does it promote weight loss? This article will answer all your questions.
What is Semaglutide, and How Does It Work?
- Semaglutide is a synthetic substance that mimics the working of GLP-1 – a hormone that regulates hunger and insulin production in the human body. Semaglutide belongs to glucagon-like peptide-1 receptor agonists (GLP-1 RAs).
To understand the working of Semaglutide, let us see how GLP-1, the body’s naturally occurring hormone, works. GLP-1 is produced in the small intestine. The body secretes it after the intake of food. GLP-1 promotes the feeling of fullness and satiation and sends the signal to stop eating. The effect of GLP-1 lasts for a couple of hours, after which we start to feel hungry again.
- GLP-1 also stimulates the secretion of insulin in the body. Insulin controls blood glucose levels and helps the body turn food into energy. Excess glucose is stored as fat in the body.
How Does Semaglutide Contribute to Weight Loss?
- Semaglutide is a structurally modified, synthetic version of the GLP-1 hormone. Due to the structural modifications, the effects of Semaglutide last longer in the body than the natural hormone. Semaglutide delays the digestive process, and the food stays in the stomach longer. This promotes the feeling of fullness and curbs hunger. As a result, fewer calories are consumed by the body, which results in gradual weight loss.
Semaglutide also interacts with the nervous system to control energy expenditure and dictate food preferences that eventually lead to suppressing appetite. Delayed gastric emptying and suppressed appetite prevent excessive intake of food. When fewer calories are available, the body will start to burn stored fat deposits as a source of energy. This promotes gradual weight loss and reduction in overall body fat.
What is The Success Rate of Semaglutide for Weight Loss?
- Multiple clinical studies and trials have been conducted to determine the suitability, safety, and effectiveness of Semaglutide for weight loss. One such study was conducted using a set of 2,000 obese adults who used Semaglutide for 68 weeks. Along with using the injectable, the participants modified their diet and incorporated an exercise regimen. After 68 weeks, it was noted that half the participants lost 15% of their body weight, while one-third lost almost 20%.
In parallel, another set of obese adults was observed for 68 weeks. They did not take Semaglutide but modified their diet and incorporated exercise into their routine. These participants lost only 2.4% of their weight. This indicates that Semaglutide made a considerable difference in reducing the weight of obese adults.
- Multiple other studies have been conducted, and they all indicate the effectiveness of Semaglutide for weight loss.
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