The Optimum Dosage of Semaglutide for Weight Loss

Learn how to adjust the dosage of semaglutide for weight loss according to your body type and lifestyle

Obesity is a life-limiting illness. It is the precursor for several cardiometabolic disorders such as high blood pressure, heart attack, diabetes, stroke, and fatty liver disease. Obesity impacts the quality of life and leads to premature mortality. Sedentary lifestyle and unrestrained consumption of unhealthy food have increased the percentage of obese individuals. Statistical analysis shows that by 2030, 50% of US adults will be categorized as obese.

Eating a healthy and nutrient-dense diet, avoiding empty carbs and unhealthy fat, and regularly exercising are key to weight loss and management. However, this is usually insufficient for individuals suffering from chronic obesity. Obesity requires medical intervention along with adopting a healthy lifestyle.

Semaglutide, or Wegovy, has emerged as a miracle anti-obesity drug. Initially used for treating type-2 diabetes, Wegovy can also result in significant weight loss. Semaglutide is classified as a glucagon-like-peptide-1 (GLP-1) receptor agonist. Basically, it mimics the function of a human hormone that controls the feeling of hunger and satiation and regulates insulin production in response to food intake.

Semaglutide delays gastric emptying and promotes the feeling of satiation. As a result, people don’t feel hungry as often, which limits their food intake. Lesser calorie intake, reduced blood sugar, and regular exercise can help reduce weight and combat obesity.

Semaglutide is administered as an injectable. It is a prescription medicine approved for individuals with an initial BMI of 27 to 30 kg/m2 and suffering from at least one weight-related comorbid condition.

For the best results, patients should adhere to the prescribed dosage of Semaglutide. Let us explore the optimal dosage of semaglutide for effective weight loss.

Optimal Dosage of Semaglutide for Weight Loss

Semaglutide interferes with the working of the Gastrointestinal Tract. It is a prescription medicine with considerable side effects. The body requires time to adjust to the medicine gradually. Therefore, in the beginning, the medicine dosage is quite low. The dose is increased gradually over 17 weeks. At this point, a maintenance dose of 2.4 mg/week is administered once a week.

The approved dosage schedule for Wegovy is as follows:

  • A 0.25 mg injection is administered subcutaneously per week for the first four weeks.
  • For weeks 5 through 8, the dosage is increased to 0.5 mg. One injection of 0.5 mg is administered subcutaneously per week.
  • From weeks 9 through 12, a 1 mg injection is administered subcutaneously per week.
  • From weeks 13 through 16, a 1.7 mg injection is administered subcutaneously per week.
  • From week 17 and onwards, the dosage remains constant. A 2.4 mg injection is administered subcutaneously per week.

Dosage Intolerance

dosage of semaglutideThe gradual increase in the dosage allows the body to adjust to the medicine. However, in some cases, the body is unable to tolerate the highest dose of 2.4 mg once a week. If the side effects of Semaglutide worsen after the administration of 2.4 mg injection, it means the body is not tolerating Semaglutide at its maximum dose.

For such cases, doctors recommend the following course of action:

  • For a maximum period of 4 weeks, the dosage can be temporarily decreased to 1.7 mg per week.
  • After 4 weeks, the dosage should be increased to 2.4 mg per week.
  • However, if the side effects worsen again, it indicates that semaglutide is not a suitable treatment for the individual. In such a case, stop the treatment altogether to avoid medical complications.

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